The Auglass Dallas, headquartered in the Dallas area, is one of the leading manufacturers of graphene. Graphene is a material that can exhibit amazing mechanical and thermal properties. Besides its obvious applications for electronics, this technology is also useful in the Biomedical field.
Graphene is a monolayer of sp2-hybridized carbon atoms that is ideal for biomedical applications. It has a high area/volume ratio, a high thermal conductivity, superior mechanical properties, and high electron mobility at room temperature. This makes graphene a good choice for neural recording, and it could also be used for nerve guidance devices.
For this study, the interaction between bare graphene and PC12 cells was assessed. We found that both the bare graphene and the coated graphene were not affected by the presence of NGF in the culture medium. Moreover, after cell removal, the bare graphene did not undergo a change in morphology.
Poly-D-Lysine (PDL) and laminin coatings were applied to the substrates. Generally, PDL is considered to be suitable for DRG neurons. However, in our study, the results revealed that PC12 cells were able to survive and differentiate on noncoated graphene. Interestingly, the graphene average neurite length was significantly longer than that of glass and SiC. In addition, the number of neurites per cell was lower on graphite and SiC.